Rome, Italy, October 11-14, 2023

Poster Session 2

FRIDAY, OCTOBER 13, 2023


14:00-15:00 Poster Session 2
Session Chairs:
Ivana Vaneckova, Czech Academy of Sciences, Prague, Czech Republic
Kelly Hyndman, University of Alabama, Birmingham, U.S.A.

PROFILING THE ENDOTHELIN SYSTEM RNA AND PROTEIN IN RODENT AND HUMAN KIDNEYS OF BOTH SEXES
Kelly Hyndman
University of Alabama at Birmingham, Medicine, Nephrology, Birmingham, USA

ZENITH: DETERMINING THE BENEFIT OF COMBINED ZIBOTENTAN AND DAPAGLIFLOZIN IN PATIENTS WITH PROTEINURIC CKD
Pavlos Kashioulis
Late-Stage Development, Cardiovascular, Renal, and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

VASCULAR ENDOTHELIUM-DERIVED ENDOTHELIN 1 MEDIATES KIDNEY INFLAMMATION IN MALE BUT NOT FEMALE MICE ON A HIGH SALT DIET
Jennifer Pollock
University of Alabama at Birmingham, Birmingham, USA

ALPORT MOUSE MODEL SHOWS SIGNIFICANT DOWNREGULATION OF NECTIN-4 WITH PARTIAL RECONSTITUTION AFTER ETAR AND ETBR BLOCK
Melanie von Brandenstein
University Hospital of Cologne, Institute of Urology, Cologne, Germany

ETAR AND ETBR DEPENDENT DOWNREGULATION OF TROP-2 IN MOUSE MODEL OF ALPORT SYNDROME
Melanie von Brandenstein
University Hospital of Cologne, Institute of Urology, Cologne, Germany

ENDOTHELIN-1 ENHANCES GENE EXPRESSIONS OF IP RECEPTOR PATHWAY
Hidekazu Maruyama
National Hospital Organization Kasumigaura Medical Center, Tsuchiura, Japan

CUMULATIVE CONCENTRATION OF ENDOTHELIN-1 AND ENDOTHELIN-3 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION: BEYOND THE ENDOTHELIAL DYSFUNCTION
Astrid Karina Putri
Department of Cardiology and Vascular Medicine, Gadjah Mada University / Sardjito General Hospital, Yogyakarta, Indonesia

REDUCED TRANS-MYOCARDIAL EXTRACTION OF ENDOTHELIN-1 IN CARDIAC ALLOGRAFT VASCULOPATHY
George Abraham
Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK

ENDOTHELIAL ET-1 EXPRESSION IN PRE AND PERIMENOPAUSAL WOMEN
Angelica del Vecchio
University of Delaware, Department of Kinesiology and Applied Physiology, Newark, DE, USA

CRISPRI-PERTURB-SEQ IN ENDOTHELIAL CELLS LINKS GENETIC VARIATION IN ENDOTHELIN-1 TO RISK OF CORONARY ARTERY DISEASE AND HYPERTENSION
Rajat Gupta
Harvard Medical School, Boston, USA

HIGHER SERUM ENDOTHELIN-1 LEVEL RELATED TO LOWER PHYSICAL ACTIVITY AND INDEPENDENTLY ASSOCIATED WITH UNMET WHO-RECOMMENDED PHYSICAL ACTIVITY IN CORONARY ARTERY DISEASE
Anggoro Budi Hartopo
Department Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada, Yogyakarta, Indonesia

ENDOTHELIN-1 INDUCES BROWNING IN 3T3-L1 ADIPOCYTES
Chi-Chang Juan
Institute of Physiology, National Yang Ming Chiao Tung University, Taipei, Taiwan

EFFECT OF ENDOTHELIN-1 ON SKELETAL MUSCLE MYOGENESIS AND DEVELOPMENT
Shui-Yu Liu
Institutes of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

COMBINATION OF ZIBOTENTAN AND DAPAGLIFLOZIN FOR TREATMENT OF CIRRHOSIS WITH CLINICALLY SIGNIFICANT PORTAL HYPERTENSION: RATIONALE AND DESIGN OF PHASE 2 STUDY
Pawel Petryszyn
AstraZeneca, Warsaw, Poland

ELEVATED GLUCOSE LEVELS INCREASE ET-1sPRODUCTION AND METABOLISM IN CEREBRAL ENDOTHELIAL CELLS
Auburn Berry
University of Colorado, Boulder, USA

CO-LOCALIZATION OF THE SODIUM-GLUCOSE CO-TRANSPORTER-2 CHANNEL (SGLT2) WITH ENDOTHELIN ETA AND ETB RECEPTOR
Anthony Davenport
Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK

ET-TRAPS NOVEL THERAPEUTIC BIND TO EXCESS ENDOTHELIN-1 IN THE BODY TO POTENTLY REDUCE PATHOLOGICAL MARKERS IN DIABETES WITHOUT TOXICITY
Arjun Jain
Physiology, Development and Neuroscience, University of Cambridge, UK, Cambridge, UK

ENDOTHELIN-1 (ET-1) MEDIATES ENDOTHELIAL MESENCHYMAL TRANSITION IN DIABETES: IMPACT OF POTENTIAL SEX DIFFERENCES
Kareem Abdelsaid
Medical University of South Carolina, Charleston, USA

MURINE ALPORT SYNDROME AS MODEL SYSTEM TO EVALUATE MICRORNA-BASED DIAGNOSIS AS WELL AS THERAPY OF A SPECIFIC ET-A/B RECEPTOR BLOCK FOR PROXIMAL TUBULAR PROTECTION INSPITE OF CONTINUOUS PROTEINURIA
Jochen Fries
University Hospital of Cologne, Institute of Pathology, Cologne, Germany

ENDOTHELIN LIGANDS INDUCE A DISTINCT G-PROTEIN AND BETA-ARRESTIN ACTIVITY ON THE TYPE A ENDOTHELIN RECEPTORS IN HEK293 CELLS
Risa Ramadhiani
Laboratory of Clinical Pharmaceutical Science, Kobe PharmaceuticalUniversity, Kobe, Japan